Human body and fat

Why do some people end up gaining weight while there are others who don’t? Is there a simple answer to this question? We’re all familiar with the role of diet and exercise in maintaining a healthy weight, but what if there’s something else at work?

Is weight management all about burning more calories than you are consuming? If the answer was so simple, then why do some people who eat healthy and exercise regularly still gain weight?

The human body is a complex system, and the answer to this perplexing question lies in an equally complex hormone known as Leptin.

Women Measuring Belly Fat With Tool Caused Due to Harmone Imbalance

Role of hormones in Fat Regulation

Our body is a complex system, and the way it regulates blood sugar and fat levels is largely determined by hormones. Hormones are chemical messengers that travel throughout our bodies, controlling various functions like metabolism, digestion, reproduction, growth, and development. When these hormones are out of balance or not functioning properly, we may experience weight gain or other health issues. Understanding how our body produces and responds to different hormones can help us make better decisions about our diet and lifestyle in order to maintain healthy blood sugar and fat levels.

What is Leptin?

Leptin is a hormone that regulates our body weight by controlling how much fat we store and how much energy we burn. Leptin is secreted by fat cells and travels to the brain, where it tells your body how much energy you have. If leptin levels are too low, your body may store more fat than necessary, resulting in weight gain and obesity.
An Infographic showing Leptin harmone Impact on human body

What is Leptin Resistance?

Leptin resistance occurs when the brain cannot recognize leptin signals, and your body becomes insensitive to them. When your body does not respond to leptin levels or you develop Leptin resistance, it can lead to an increased appetite and decreased metabolic rate.

This can cause people to consume more calories than they need and store them as excess fat. As a result, people who are Leptin resistant may find it difficult to lose weight through dieting or exercise alone.

Remember, people who are obese or overweight tend to have higher levels of Leptin in their bodies. However, due to leptin resistance, they still feel less satiated and hungry. 

Diagram Showing Leptin Resistance And Obesity

What causes Leptin Resistance?

Leptin resistance develops over time by various factors, including unhealthy eating habits, a lack of physical activity, and chronic stress. Poor sleep quality can also lead to leptin resistance as it disrupts the hormones in our bodies.

Other factors contributing to leptin resistance include hormone imbalances, medications, and chronic inflammation.

Women Watching Non Vegetarian Food Plate Holding Knife and Fork

What can you do you overcome Leptin Resistance?

Can you overcome Leptin Resistance by eating healthy and being active alone?

While these are important steps, remember Leptin Resistance will make you feel hungrier, making it harder to stick to a calorie deficit. Leptin Resistance will also signal your body to conserve energy, and this, in turn, will make it harder for you to burn calories or stay active.

So how do you come out of this vicious cycle?  To achieve long-term weight loss, you need to improve your leptin sensitivity in the first place. The good news is that there are supplements that can help. Certain nutrients and herbs can help support healthy leptin levels.

What happens once your leptin levels start to improve?

Once your leptin levels start to improve, your body will respond better to normal hunger cues, enabling you to eat a healthy and balanced diet. Your energy levels will improve and will allow you to stay active, and this, in turn, can help you to lose weight.

Over time your leptin resistance will decrease, enabling you to reach and maintain a healthy weight.

Women Doing Rigrous Excercise To Reduce Fat

What are leptin supplements?

Leptin supplements are designed to help improve leptin sensitivity by reducing inflammation. Supplements labeled as ‘Leptin Support’ or ‘Leptin Pills’ do not contain the hormone itself. They contain ingredients such as omega-3, soluble fibers, and green tea, which have all been linked to improving leptin sensitivity; however, the effects of these supplements in improving leptin sensitivity are not established, and more research needs to be done.

Are there supplements that can actually help you overcome Leptin Resistance?

Yes, some supplements can help improve leptin sensitivity. A number of natural compounds, such as African Mango(Irvingia gabonensis), Cissus quadrangularis, and Dyg-400(Dichrostachys glomerate), have been found to help improve leptin sensitivity. Adding these supplements to your diet can help you lose weight and maintain healthy leptin levels over time.

African Mango or Irvingia gabonensis(#1.)

IGOB-131 is a patented extract from the African Mango. In a 10-week Clinical Study published in the Journal Lipids in Health and Disease, IGOB-131 demonstrated a number of benefits to achieve and maintain target weight:

  • Helps prevent fatty acid formation
  • Helps block the breakdown of foods into blood sugar
  • Helps suppress the enzyme that prevents the formation of fat from blood sugar

Cissus quadrangularis(#2.)

CQR-300 is a unique, patented extract of Cissus quadrangularis, an indigenous medicinal plant of West Africa and India. In 2005, researchers at Oxford University conducted a study of CQR-300 and found a wide range of health benefits, including:

  • Helps inhibits enzyme amylase activity to slow starch metabolism
  • Helps improve the body’s ability to burn stored fat and build lean muscle mass
  • Supports healthy serotonin levels

Dyg-400, or Dichrostachys glomerate(#3.)

Dyg-400, or Dichrostachys glomerate, originates from a rare spice from the jungles of Cameroon. This powerful ingredient helps the body use sugar more efficiently for energy, so it doesn’t get stored as fat. In a clinical study, DYG-400 was found to help improve metabolic function and reduce fat deposits along with other health benefits, including:

  • Helps improve leptin (hunger hormone) function to reduce cravings
  • Acts as a powerful antioxidant
  • Helps support blood-sugar hormone sensitivity, which triggers fat metabolism

These supplements, when taken alongside a healthy diet, regular exercise, and good lifestyle choices, can help reduce and overcome leptin resistance, enabling you to achieve your weight loss goals.


  • Hormones are chemical messengers that travel throughout our bodies, controlling various functions like metabolism, digestion, reproduction, growth, and development.
  • The Hormone Leptin signals the brain when we are full and have energy.
  • Leptin Resistance causes us to overeat, become overweight, and suffer from other health issues.
  • Leptin resistance is difficult to overcome with diet and exercise alone.
  • Naturally occurring herbs and fibers such as African Mango, Cissus Quadrangularis, and Dyg-400 have been found to aid in improving leptin sensitivity.
  • When taken alongside a healthy diet and exercise, these natural supplements can help reduce leptin resistance and enable you to reach your target weight.

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Tetrogen ingredients infographics

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